Why do women live longer than men? A review from a biological point of view
PDF (Español (España))

Keywords

longevity
gender gap
life expectancy
immune system
sex hormones
genetic dimorphism

How to Cite

López Ramos, C. (2020). Why do women live longer than men? A review from a biological point of view. Spanish Journal of Environmental Health, 20(2), 160–166. Retrieved from https://ojs.diffundit.com/index.php/rsa/article/view/1047

Abstract

A fact that has been repeatedly observed over the last 200 years is that women live longer than men. Therefore, this difference in longevity cannot be solely accounted for by the different sociocultural roles played by each of the sexes in the core of a community since this gap remains consistent in societies that greatly differ in their customs, settlement locations, and lifestyles. Thus, over several decades an effort has been made to determine whether there is a biological mechanism that could explain this difference. This research has produced a wide range of results that could be summarized in four main hypotheses based on genetic disparities, the role of sex hormones, immune system dimorphism, and body fat distribution. However, determining which one of these hypotheses plays the most decisive role in the biology of the gender longevity gap has proven quite an arduous task. Moreover, these hypotheses are not mutually exclusive; instead, they link the differences in lifestyle behaviour of men and women in an attempt to elucidate the reason why women live longer than men, a highly peculiar and remarkable fact of human existence.
PDF (Español (España))

References

McKeown T. Los Orígenes de Las Enfermedades Humanas. Barcelona: Editorial Crítica; 1990.

Doll R. Health and the environment in the 1990s. Am J Public Health. 1992; 82(7):933-941. doi:10.2105/ajph.82.7.933.

Ginter E, Simko V. Women live longer than men. Bratisl Lek List. 2013; 114(2):45-49. doi:10.4149/BLL_2013_011.

Instituto Nacional de Estadística (INE). Esperanza de Vida al Nacimiento según sexo. Indicadores de Mortalidad. Resultados nacionales. [actualizado en 2019; citado 10/01/2020] Disponible en: https://www.ine.es/jaxiT3/Tabla.htm?t=1414.

Austad SN, Bartke A. Sex Differences in Longevity and in Responses to Anti-Aging Interventions: A Mini-Review. Gerontology. 2016; 62(1):40-46. doi:10.1159/000381472.

Universidad de California (Berkeley), Instituto Max Plank para la Investigación Demográfica. Human Mortality Database. [actualizado en 2019; citado 10/01/2020] Disponible en: https://www.mortality.org/.

Kontis V, Bennett JE, Mathers CD, Li G, Foreman K, Ezzati M. Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet. 2017; 389(10076):1323-1335.

Kaeberlein M. Longevity and aging. F1000Prime Rep. 2013; 5:5. doi:10.12703/P5-5.

Ministerio de Sanidad, Servicios Sociales e Igualdad. Patrones de mortalidad en España, 2016. Madrid: Ministerio de Sanidad, Servicios Sociales e Igualdad, 2019.

Verbrugge LM, Wingard DL, Features Submission HC. Sex DifferentialsinHealthandMortality.WomenHealth.1987;12(2):103-145. doi:10.1300/J013v12n02_07.

Wingard DL. The Sex Differential in Morbidity, Mortality, and Lifestyle. Annu Rev Public Health. 1984; 5(1):433-458. doi:10.1146/ annurev.pu.05.050184.002245.

Austad SN, Fischer KE. Sex Differences in Lifespan. Cell Metab. 2016; 23(6):1022-1033. doi:10.1016/j.cmet.2016.05.019.

Bronikowski AM, Altmann J, Brockman DK, et al. Aging in the natural world: comparative data reveal similar mortality patterns across primates. Science. 2011; 331(6022):1325-1328. doi:10.1126/ science.1201571.

Austad SN. Why women live longer than men: sex differences in longevity. Gend Med. 2006; 3(2):79-92.

Kenyon CJ. The genetics of ageing. Nature. 2010; 464(7288):504- 512. doi:10.1038/nature08980.

Maklakov AA, Lummaa V. Evolution of sex differences in lifespan and aging: Causes and constraints. BioEssays. 2013;35(8):717-724. doi:10.1002/bies.201300021.

Brengdahl M, Kimber CM, Maguire‐Baxter J, Friberg U. Sex differences in life span: Females homozygous for the X chromosome do not suffer the shorter life span predicted by the unguarded X hypothesis. Evolution (N Y). 2018; 72(3):568-577.

Tower J, Arbeitman M. The genetics of gender and life span. J Biol. 2009; 8(4):38. doi:10.1186/jbiol141.

Tower J. Sex-specific regulation of aging and apoptosis. Mech Ageing Dev. 2006;127:705-718. doi:10.1016/j.mad.2006.05.001.

Tower J. Sex-Specific Gene Expression and Life Span Regulation. Trends Endocrinol Metab. 2017; 28(10):735-747. doi:10.1016/j. tem.2017.07.002.

Spector A. Review: Oxidative Stress and Disease. J Ocul Pharmacol Ther. 2000;16(2):193-201. doi:10.1089/jop.2000.16.193.

Min K-J, Lee C-K, Park H-N. The lifespan of Korean eunuchs. Curr Biol. 2012;22(18):R792-R793. doi:10.1016/j.cub.2012.06.036.

Hamilton JB, Mestler GE. Mortality and Survival: Comparison of Eunuchs with Intact Men and Women in a Mentally Retarded Population. J Gerontol. 1969; 24(4):395-411. doi:10.1093/geronj/24.4.395.

Shores MM, Matsumoto AM, Sloan KL, Kivlahan DR. Low Serum Testosterone and Mortality in Male Veterans. Arch Intern Med. 2006; 166(15):1660-1665. doi:10.1001/archinte.166.15.1660.

Lobo RA, Davis SR, De Villiers TJ, Gompel A, Henderson VW, Hodis HN. Prevención de enfermedades después de la menopausia. Climacteric. 2014; 17:540-556.

Panico S, Galasso R, Celentano E,lCiardullo AV, Frova L, Capocaccia M et al. Large-scale hormone replacement therapy and life expectancy: results from an international comparison among European and North American populations. Am J Public Health. 2000; 90(9):1397-1402. doi:10.2105/ajph.90.9.1397.

Sacks FM, Walsh BW. The Effects of Reproductive Hormones on Serum Lipoproteins : Unresolved Issues in Biology and Clinical Practice. Ann N Y Acad Sci. 1990; 592:272-285. doi:10.1111/j.1749-6632.1990. tb30339.x.

Hao W, Friedman A. The LDL-HDL profile determines the risk of atherosclerosis: a mathematical model. PLoS One. 2014; 9(3):e90497-e90497. doi:10.1371/journal.pone.0090497.

Nilsson BO. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm Res. 2007; 56(7):269-273. doi:10.1007/ s00011-007-6198-z.

Candore G, Balistreri CR, Colonna-Romano G,lLio D. Gender- Related Immune-Inflammatory Factors, Age-Related Diseases, and Longevity. Rejuvenation Res. 2010;13(2-3):292-297. doi:10.1089/ rej.2009.0942.

Spence RD, Voskuhl RR. Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration. Front Neuroendocrinol. 2012; 33(1):105-115. doi:10.1016/j. yfrne.2011.12.001.

Vegeto E, Belcredito S, Etteri S,lGhisletti S, Brusadelli A, Meda C et al. Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci. 2003; 100(16):9614 LP - 9619. doi:10.1073/pnas.1531957100.

Malutan AM, Dan M, Nicolae C, Carmen M. Proinflammatory and anti-inflammatory cytokine changes related to menopause. Prz menopauzalny = Menopause Rev. 2014; 13(3):162-168. doi:10.5114/ pm.2014.43818.

Straub RH. The Complex Role of Estrogens in Inflammation. Endocr Rev. 2007; 28(5):521-574. doi:10.1210/er.2007-0001.

Kayali R, Çakatay U, Tekeli F. Male rats exhibit higher oxidative protein damage than females of the same chronological age. Mech Ageing Dev. 2007; 128(5):365-369. doi:10.1016/j.mad.2007.03.003.

Ide T, Tsutsui H, Ohashi N,lHayashidani S, Suematsu N, Tsuchihashi M et al. Greater oxidative stress in healthy young men compared with premenopausal women. Arterioscler Thromb Vasc Biol. 2002; 22(3):438-442. doi:10.1161/hq0302.104515.

Kander MC, Cui Y, Liu Z. Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases. J Cell Mol Med. 2017; 21(5):1024-1032. doi:10.1111/jcmm.13038.

Czubryt MP, Espira L, Lamoureux L, Abrenica B. The role of sex in cardiac function and disease. Can J Physiol Pharmacol. 2006; 84(1):93-109. doi:10.1139/y05-151.

Yang D, Li J, Yuan Z, Liu X. Effect of hormone replacement therapy on cardiovascular outcomes: a meta-analysis of randomized controlled trials. PLoS One. 2013; 8(5):e62329-e62329. doi:10.1371/ journal.pone.0062329.

Oertelt-Prigione S. The influence of sex and gender on the immune response. Autoimmun Rev. 2012; 11:479-485. doi:10.1016/j. autrev.2011.11.022.

Lawrence DA, McCabe MJ. Immunomodulation by metals. Int Immunopharmacol. 2002;2(2):293-302. doi:10.1016/S1567-5769(01)00180-1.

McCombe PA, Greer JM. Capítulo 24. Sexual Dimorphism in the Immune System. In: Rose NR, Mackay IRBT-TAD (Fifth E, eds. The Autoimmnune Diseases. Boston: Academic Press; 2014:319-328. doi:10.1016/B978-0-12-384929-8.00024-1.

Hunter P. The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. EMBO Rep. 2012;13(11):968- 970. doi:10.1038/embor.2012.142.

Roved J, Westerdahl H, Hasselquist D. Hormones and Behavior Sex differences in immune responses : Hormonal effects, antagonistic selection, and evolutionary consequences. Horm Behav. 2017;88:95-105. doi:10.1016/j.yhbeh.2016.11.017.

Bouman A, Jan Heineman M, Faas MM. Sex hormones and the immune response in humans. Hum Reprod Update. 2005; 11(4):411-423. doi:10.1093/humupd/dmi008.

Ansar Ahmed S, Penhale WJ, Talal N. Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am J Pathol. 1985; 121(3):531-551. https://www. ncbi.nlm.nih.gov/pubmed/3907369.

Desprat JL, Lengagne T, Dumet A, Desouhant E, Mondy N. Immunocompetence handicap hypothesis in tree frog: trade- off between sexual signals and immunity? Behav Ecol. 2015; 26(4):1138-1146. doi:10.1093/beheco/arv057.

Olsson M, Wapstra E, Madsen T, Silverin B. Testosterone, ticks and travels: a test of the immunocompetence-handicap hypothesis in free-ranging male sand lizards. Proceedings Biol Sci. 2000; 267(1459):2339-2343. doi:10.1098/rspb.2000.1289.

Karastergiou K, Smith SR, Greenberg AS, Fried SK. Sex differences in human adipose tissues - the biology of pear shape. Biol Sex Differ. 2012; 3(1):13. doi:10.1186/2042-6410-3-13.

Hamdy O, Porramatikul S, Al-Ozairi E. Metabolic obesity: the paradox between visceral and subcutaneous fat. Curr Diabetes Rev. 2006; 2(4):367-373.

Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, Tokunaga K. Pathophysiology and Pathogenesis of Visceral Fat Obesity. Obes Res. 1995; 3(S2):187s-194s. doi:10.1002/j.1550-8528.1995.tb00462.x.

Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol. 2015; 402:113-119. doi:10.1016/j.mce.2014.11.029.

Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med. 2014; 371(12):1131-1141.

Xu Y, Nedungadi TP, Zhu L,lSobhani N, Irani BG, Davis KE et al. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab. 2011; 14(4):453-465. doi:10.1016/j.cmet.2011.08.009.

Buffenstein R, Poppitt SD, McDevitt RM, Prentice AM. Food intake and the menstrual cycle: a retrospective analysis, with implications for appetite research. Physiol Behav. 1995; 58(6):1067-1077.

Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev. 2013; 34(3):309-338. doi:10.1210/er.2012-1055.

The articles published in this journal are subject to the following terms and conditions:

  1. The journal retains copyright of the articles published, and encourages and permits their reuse under the licence indicated at point 2.
  2. The articles are published in the online edition of the journal under licence Creative Commons Attribution-Non Commercial 4.0 (CC BY-NC 4.0). They can be copied, used, disseminated, transmitted, and publicly displayed, providing that the authorship, URL address and the Journal are cited, and that no commercial use is made of them.
  3. The authors agree with terms of licence use of the journal, with the self-archiving conditions and with the open access policy.
  4. In the event of reuse of the articles published, the existence and specifications of the terms of licence use must be mentioned, in addition to citing the authorship and original source of the their publication.

Downloads

Download data is not yet available.