Bibliometric Analysis of The Ecotoxicological Effects of Ivermectin
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Keywords

antiparasitic
pharmaceutical pollution
drug pollution
environmental health
COVID-19

How to Cite

Costa, R. dos S., Medeiros, A. N., do Amaral, V. S., & Navoni, J. A. (2022). Bibliometric Analysis of The Ecotoxicological Effects of Ivermectin. Spanish Journal of Environmental Health, 22(2), 208–216. Retrieved from https://ojs.diffundit.com/index.php/rsa/article/view/1154

Abstract

Ivermectin is an antiparasitic used in human medicine and veterinary medicine. Moreover, its use intensified in Brazil during the pandemic as an early treatment for COVID-19. Bearing in mind that drugs enter the environment via different pathways, ecotoxicological studies are essential to understanding the effects of these compounds on biota. The aim of this study was to perform a bibliometric analysis of the ecotoxicological effects of ivermectin. Searches were conducted using different English, Portuguese and Spanish descriptors in different databases within the 2010-2021 time window. The papers found were subjected to inclusion and exclusion criteria and subsequently studied. Fourteen publications, with records going all the way back to 2012, were assessed. According to their type, most papers were classified as original studies and revealed that the predominant test organisms were flies. In terms of subject areas, the studies fell within the fields of Environmental Science, Toxicology, Molecular Biochemistry, Pharmacology and Pharmacy and Multidisciplinary Chemistry. In all of the papers studied, there was a case of association of researchers from different countries as well as a predominance of English manuscripts. Word cloud analysis based on the keywords highlighted a concern with the impacts of this antiparasitic on the biota present in manure. As a result of the survey conducted, environmental monitoring of this substance and the performance of experiments that contemplate the current situation of occurrence of this drug in different environmental matrices are recommended.

PDF (Português (Portugal))

References

Quadra GR, Souza DHO, Costa RDS, Fernandez MADS. Do pharmaceuticals reach and affect the aquatic ecosystems in Brazil? A critical review of current studies in a developing country. Environ. Sci. Pollut. Res. 2017;24:1200-18.

Souza HDO, Costa RDS, Quadra GR, Fernandez MAS. Pharmaceutical pollution and sustainable development goals: Going the right way? Sustain. Chem. Pharm. 2021;1:100428.

Quispe-Cañari JF, Fidel-Rosales E, Manrique D, Mascaró-Zan J, Huamán-Castillón KM, Chamorro-Espinoza SE, et al. Self- medication practices during the COVID-19 pandemic among the adult population in Peru: A cross-sectional survey. Saudi Pharm. J. 2021;29:1-11.

Melo JRR, Duarte EC, Moraes MVD, Fleck K, Arrais PSD. Automedicação e uso indiscriminado de medicamentos durante a pandemia da COVID-19. Cad. Saúde Públ. 2021;37:e00053221.

Lescano J, Pinto C. Ivermectina dentro del protocolo de tratamiento para la COVID-19 en Perú: Uso sin evidencia científica. Salud Tecnol. Vet. 2020;8:27-34.

U.S. Food and Drug Administration (FDA). Why You Should Not Use Ivermectin to Treat or Prevent COVID-19. [atualizado em 2021; citado em 20 de agosto de 2022] Disponível em: https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use- ivermectin-treat-or-prevent-covid-19.

Vercruysse J, Claerebout E. Macrocyclic Lactones. [atualizado em 2014; citado 07-10-2021] Disponível em: https://www.merckvetmanual.com/pharmacology/anthelmintics/macrocyclic-lactones.

National Center for Biotechnology Information. PubChem Compound Summary for CID 6321424, Ivermectin. [atualizado em 2021; citado em 07 de outubro de 2021] Disponível em: https://pubchem.ncbi.nlm.nih.gov/compound/Ivermectin.

Omura S. Ivermectin: 25 years and still going strong. Int. J. Antimicrob. Agents. 2008;31:91-8.

Delayte EH, Otsuka M, Larsson CE, Castro RCC. Eficácia das lactonas macrocíclicas sistêmicas (ivermectina e moxidectina) na terapia da demodicidose canina generalizada. Arq. Bras. Med. Vet. Zootec. 2006;58:31-8.

Cezar AS, Vogel FS, Sangioni LA, Antonello AM, Camillo G, Toscan G, et al. Anthelmintic action of different formulations of macrocyclic lactones on resistant strains of nematodes of cattle. Pesq. Vet. Bras. 2010;30:523-8.

Löffler D, Ternes TA. Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography–tandem mass spectrometry. J. Chromatogr. A. 2003;1021:133-44.

Fatoki OS, Opeolu BO, Genthe B, Olatunji OS. Multi-residue method for the determination of selected veterinary pharmaceutical residues in surface water around Livestock Agricultural farms. Heliyon 2018;4:e01066.

Schmitt H, Römbke J. The Ecotoxicological Effects of Pharmaceuticals (Antibiotics and Antiparasiticides) in the Terrestrial Environment - a Review. En: Kümmerer, K. (eds) Pharmaceuticals in the Environment. Springer, Berlin, Heidelberg. 2008. pp. 285-303.

Bai SH, Ogbourne S. Eco-toxicological effects of the avermectin family with a focus on abamectin and ivermectin. Chemosphere 2016;154:204-14.

Zhang X, Xia P, Wang P, Yang J, Baird DJ. Omics advances in ecotoxicology. Environ. Sci. Technol. 2018;52:3842-51.

Bufrem L, Prates Y. O saber científico registrado e as práticas de mensuração da informação. Cienc. da Inf. 2005;34:9-25.

Olisah C, Okoh OO, Okoh AI. Global evolution of organochlorine pesticides research in biological and environmental matrices from 1992 to 2018: A bibliometric approach. Emerg. Contam. 2019;5:157-67.

Ramírez-Malule H, Quiñones-Murillo DH, Manotas-Duque D. Emerging contaminants as global environmental hazards. A bibliometric analysis. Emerg. Contam. 2020;6:179-93.

Baćmaga M, Wyszkowska J, Kucharski J. The effect of the Falcon 460 EC fungicide on soil microbial communities, enzyme activities and plant growth. Ecotoxicology 2016;25:1575-87.

Scott JG, Roush RT, Liu N. Selection of high-level abamectin resistance from field-collected house flies, Musca domestica. Experientia 1991;47:288-91.

Calderon MR, Almeida CA, González P, Jofré MB. Influence of water quality and habitat conditions on amphibian community metrics in rivers affected by urban activity. Urban Ecosyst. 2019;22:743-55.

Kryger U, Deschodt C, Scholtz CH. Effects of fluazuron and ivermectin treatment of cattle on the structure of dung beetle communities. Agric. Ecosyst. Environ. 2005;105:649-56.

Mahdjoub H, Blanckenhorn WU, Lüpold S, Roy J, Gourgoulianni N, Khelifa R. Fitness consequences of the combined effects of veterinary and agricultural pesticides on a non-target insect. Chemosphere 2020;250:126271.

Vokřál, I., Šadibolová M, Podlipná R, Lamka J, Prchal L, Sobotová D, et al. Ivermectin environmental impact: Excretion profile in sheep and phytotoxic effect in Sinapis alba. Ecotoxicol. Environ. Saf. 2019;169:944-9.

Zortéa T, Segat JC, Maccari AP, Sousa JP, Da Silva AS, Baretta D. Toxicity of four veterinary pharmaceuticals on the survival and reproduction of Folsomia candida in tropical soils. Chemosphere 2017;173:460-5.

Blanckenhorn WU, Puniamoorthy N, Schäfer MA, Scheffczyk A, Römbke, J. Standardized laboratory tests with 21 species of temperate and tropical sepsid flies confirm their suitability as bioassays of pharmaceutical residues (ivermectin) in cattle dung. Ecotoxicol. Environ. Saf. 2013;89:21-8.

Blanckenhorn WU, Puniamoorthy N, Scheffczyk A, Römbke J. Evaluation of eco-toxicological effects of the parasiticide moxidectin in comparison to ivermectin in 11 species of dung flies. Ecotoxicol. Environ. Saf. 2013;89:15-20.

Jochmann R, Blanckenhorn WU. Non-target effects of ivermectin on trophic groups of the cow dung insect community replicated across an agricultural landscape. Basic Appl Ecol. 2016;17:291-9.

Martínez I, Lumaret JP, Zayas RO, Kadiri, N. The effects of sublethal and lethal doses of ivermectin on the reproductive physiology and larval development of the dung beetle Euoniticellus intermedius (Coleoptera: Scarabaeidae). Can. Entomologist. 2017;149:461-72.

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