Novos modelos de células humanas para compreender como os poluentes ambientais afetam o desenvolvimento cerebral
PDF (Español (España))

Como Citar

Briz Herrezuelo, V., Peña López, A., & Ramos, J. J. (2026). Novos modelos de células humanas para compreender como os poluentes ambientais afetam o desenvolvimento cerebral. Revista Espanhola De Saúde Ambiental, 26(1), 105–107. Obtido de https://ojs.diffundit.com/index.php/rsa/article/view/1936

Resumo

Não disponível.

PDF (Español (España))

Referências

Rauen KA. The RASopathies. Annu. Rev. Genomics Hum. Genet. 2013; 14:355–69.

Geo$ray MM et al. Autism Spectrum Disorder Symptom Pro!le Across the RASopathies. Front. Psychiatry. 2021; 11:585700.

Naylor PE et al. Neuropsychiatric phenotypes in children with Noonan syndrome. Dev. Med. Child Neurol. 2023; 65:1520–9.

Wingbermühle E et al. Cognitive Phenotype and Psychopathology in Noonan Syndrome Spectrum Disorders through Various Ras/MAPK Pathway Associated Gene Variants. J. Clin. Med. 2022; 11:1–15.

López-Merino E. et al. Di$erent Ras isoforms regulate synaptic plasticity in opposite directions. EMBO J.2025; 1–28.

López-Merino E, Cuartero MI, Esteban JA, Briz V. Perinatal exposure to pesticides alters synaptic plasticity signaling and induces behavioral de!cits associated with neurodevelopmental disorders. Cell Biol. Toxicol. 2022.

Landrigan PJ. What causes autism? Exploring the environmental contribution. Curr. Opin. Pediatr. 2010; 22:219–25.

Hernández-Porras I et al. K-RasV14I recapitulates noonan syndrome in mice. Proc. Natl. Acad. Sci. U. S. A. 2014; 111:16395–400.

Schreiber J et al. Mechanisms underlying cognitive de!cits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models. Sci. Rep. 2017; 7:1256.

Reddy EP, Reynolds RK, Santos E, Barbacid M. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature. 1982; 300:149–52.

Briz V et al. The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning. Nat. Commun. 2017; 8:1–15.

Zhao X, Bhattacharyya A. Human Models Are Needed for Studying Human Neurodevelopmental Disorders. The American Journal of Human Genetics. 2018; 103:829–57.

Briz V et al. Differential estrogenic effects of the persistent organochlorine pesticides dieldrin, endosulfan, and lindane in primary neuronal cultures. Toxicological Sciences. 2011; 120:413–27.

Hu C. et al. Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages. Environ. Int. 2024; 184:108415.

Rosca A et al. Impact of environmental neurotoxic: current methods and usefulness of human stem cells. Heliyon. 2020; 6: e05773.

Creative Commons License

Este trabalho encontra-se publicado com a Creative Commons Atribuição-NãoComercial 4.0.

Direitos de Autor (c) 2026 Revista Espanhola de Saúde Ambiental

Downloads

Não há dados estatísticos.