Spanish Journal of Environmental Mutagenesis and Genomics

Current Issue

Vol. 27 No. 1 (2023)
Published May 12, 2023
51st European Environmental Mutagenesis and Genomics Society (EEMGS) & 27th Spanish Environmental Mutagenesis and Genomics Society (SEMA) meeting

This issue of the Spanish Journal of Environmental Mutagenesis and Genomics includes the abstracts of the communications presented during the 51st EEMGS & 27th SEMA meeting (May 15th-18th, 2023), including the pre- and post-congress workshops.

Full Issue
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Keynote Lectures

A. Aguilera
20
RNA-mediated genome instability and transcription-replication conflicts
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J. Surrallés
21
Chromosome instability, DNA repair deficiency and cancer: insights from Fanconi anemia
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EEMGS New Investigators

H. C. Reinardy
23
A journey in pursuit of marine genetic toxicology
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J. Sanders, R. Anthonissen, G. Johnson, T. Vanhaecke, B. Mertens
24
Mixtures of genotoxicants: does the principle of additivity applies?
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A. K. M. Rosendahl Huber, F. Muiños, A. González-Pérez, N. López Bigas
25
Estimating the mutation risks conferred by mutational processes
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D. Pritchard, G. Jenkins
26
Negative data is still useful data: investigating and detecting non-genotoxic carcinogens in vitro
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A. García-Rodríguez, J. Martín Pérez, L. Rubio, G. Banaei, R. Marcos, A. Hernández
27
Modeling human-derived in vitro barriers for environmental toxicology
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International Workshops on Genotoxicity Testing

M. Luijten, J. van Benthem, T. Morita, D. Kirkland, R. Corvi, P. Escobar, Y. Fujita, N. Koyama, F. Le Curieux, D. P. Lovell, A. Williams, S. D. Dertinger, S. Pfuhler, J. Pennings
29
Evaluation of the Standard Battery of In Vitro Genotoxicity Tests for Human Health Risk Assessment through Mathematical Modelling: A Report of the International Workshop on Genotoxicity Testing (IWGT)
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C. Beevers, Y. Uno, K. Meurer, S. Hamada, K. Hashimoto, L. Le Hegarat, D. Kirkland, M. J. LeBaron, F. Le Curieux, H. J. Martus, K. Masumura, W. Ohyama, D. J. Roberts, M. Vasquez, W. Whitwell, K. L. Witt
30
In Vivo Genotoxicity Testing Strategies: Report of the International Workshop on Genotoxicity Testing (IWGT)
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S. D. Dertinger, D. Li, C. Beevers, G. R. Douglas, R. H. Heflich, D. P. Lovell, D. J. Roberts, R. Smith, Y. Uno, A. Williams, K. L. Witt, A. Zeller, C. Zhou
31-32
Assessing the Quality and Making Appropriate Use of Historical Negative Control Data: A Report of the International Workshop on Genotoxicity Testing (IWGT)
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H. J. Martus, C. Beevers, S. Dertinger, R. Froetschl, R. Godschalk, B. Gollapudi, K. Hashimoto, D. Kirkland, S. Libertini, M. Luijten, T. McGovern, K. Sugiyama, P. White, A. Zeller
33-34
Summary of 8th IWGT in Ottawa, Canada
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New Approach Methodologies

F. Caloni
36
3Rs: from complexity to predictivity
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L. Le Hegarat
37
The human HepaRG cell line: a brief history of its use in genetic toxicology: advantages, limits and future directions
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J. Domenech, A. Villacorta, J. F. Ferrer, R. Llorens, R. Marcos, A. Hernández, J. Catalán
38
In vitro cell transforming capacity of different types of nano-plastics
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E. J. Burgers, C. J. S. Eugenio, M. M. Heldring, R. P. Sharma, L. S. Wijaya, B. van de Water, J. B. Beltman
39
In silico modelling of crosstalk between DNA damage and oxidative stress for prediction of cellular adversity
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L. Y. Hemeryck, M. De Graeve, T. Van Hecke, S. De Smet, L. Vanhaecke
40
Perspectives for DNA adductomics in large-scale exposomics: upscaling sample preparation and preprocessing data
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A. K. Olsen, S. Hartvelt, A. Jamalpoor, G. Hendriks, X. Ma, N. Duale
41
Oxidative Stress Disrupt Differentiation of Human Induced Pluripotent Stem Cells
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International Comet Assay Working Group

B. Žegura, T. Eleršek, M. Štampar
43
Advanced 3D cell models and zebrafish embryos: A bridge between in vitro and in vivo
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M. Manjanatha, J. Seo, N. Mei, X. Guo
44
Utility of 3D HepaRG spheroid model for testing genotoxicity using high-throughput CometChip platform
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M. Collía, A. Vettorazzi, A. López de Cerain, A. Azqueta
45
Use of the CometChip® for the in vitro, in vivo and Fpg-modifed assay
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L. Živković, S. Borozan, D. Topalović, V. Bajić, B. Spremo-Potparević
46
Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist
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M. L. Magenis, A. P. Damiani, I. O. Monteiro, L. S. Dagostin, R. Scussel, S. Nagashima, S. A. S. Langie, R. A. Pinho, V. M. Andrade
47
Maternal exercise during pregnancy modulates genetic and biochemical damage caused by high consumption of fructose in offspring
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Ecotoxicology

M. Farré, M. Llorca, E. Abad, K. Savvaa, A. Vega
49
The challenge of assessing contaminants of emerging concern and microplastics
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A. N. Jha
50
Assessing the Impact of Persistent and Emerging Contaminants on Aquatic Organisms
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F. Liu, K. S. Last, T. B. Henry, H. C. Reinardy
51
Hydrogen peroxide-induced oxidative damage in sea urchin (Paracentrotus lividus) DNA
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M. Hasanovic, T. Ćetković, B. Pourrut, L. Čaluk Klačar, M. Hadžić Omanović, A. Durmic-Pasic, S. Haverić, A. Haverić
52
Plant comet assay in biomonitoring of air pollution in Sarajevo, Bosnia and Herzegovina
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ECETOC

B. van Ravenzwaay
54
An Introduction to ECETOC’s workshops on Point of Departure and IVIVE modelling
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S. Schaller, R. Geci, S. Fragki, A. Paini
55
Physiologically Based Kinetic Modelling applications in Chemical Risk Assessment
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F. M. Zickgraf, V. Giri
56
Determination of point of departures based on high throughput in vitro metabolomics
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T. W. Gant
57
Summary of the ECETOC workshop from IVIVE to PODS – translating research methods to application
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R. A. Currie
58
Applying transcriptomic benchmark modelling for toxicological decision making
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DNA Repair, Chromatin Structure and Genome Stability

B. van de Kooij, A. Schreuder, R. S. Pavani, V. Garzero, A. van Hoeck, M. San Martin Alonso, D. Koerse, J. Boom, H. Mei, E. P. J. G. Cuppen, A. Nussenzweig, H. van Attikum, S. M. Noordermeer
60
Specific killing of BRCA1-deficient cancer cells by depletion of EXO1
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M. Jordano-Raya, R. R. Ariza, T. Roldán-Arjona, D. Córdoba-Cañero
61
Influence of orphan base and sequence context on the processing of AP sites by AP lyases in Arabidopsis thaliana
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E. E. Bankoglu, G. Kodandaraman, A. Geier, H. Stopper
62
Role of Phosphatase and Tensin homolog (Pten) in Insulin mediated DNA damage
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P. Weyerhäuser, G. Nagel, K. Raja, T. Nikolov, D. Pfeiffer, W. P. Roos, Y. He, P. O. Frappart, T. G. Hofmann
63
A direct role for HIPK2 in homology-directed DNA repair and the regulation of PARP inhibitor sensitivity
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A. R. Guedes, J. P. Soares, A. M. Silva , I. Gaivão
64
Could DNA damage be a useful biomarker of diagnosis and prognostic in human breast and colorectal cancer?
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B. Kaina
65
Senescence and cell death triggered by the DNA alkylation damage O6-methylguanine
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Machine Learning

S. Bryce, J. Bemis, S. Dertinger
67
Introduction to Machine Learning in Genetic Toxicology
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P. Rees, H. D. Summers, D. Harte, J. W. Wills, G. E. Johnson
68
Deep Neural Networks to Automate Scoring Of The Imaging Flow Cytometry In-Vitro Micronucleus Assay
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M. M. Heldring, L. S. Wijaya, M. Niemeijer, H. Yang, T. Lakhal, S. E. Le Dévédec, B. van de Water, J. B. Beltman
69
Towards a quantitative understanding of the DNA damage response through data-driven dynamical modeling
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New Challenges In Genotoxicity Assessment

A. Hernández
71
Understanding the health risks of exposure to micro- & nano-plastics
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M. Aloisi, P. Morciano, A. Tarola, D. Grifoni, A. M. G. Poma
72
Biological effects of chronic oral exposure to polystyrene nanoparticles in Drosophila melanogaster
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J. Kwasniewska
73
Recent achievements in micronuclei characterization
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M. Marin-Kuan, P. Rogeboz, Y. A. Hammel, H. Latado, C. Cottet-Fontannaz, B. Gentilli, P. Serrant, E. Omer, S. Koster, A. Patin
74
Novel methodology to assess genotoxicity in Food Contact Materials (FCM)
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error-corrected Next-Generation Sequencing

C. Valentine
76
Genomic Safety Assessment with ecNGS: The Next Generation
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J. Zavadil
77
NGS and toxicogenomic signatures of human carcinogens
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S. H. Reed, P. van Eijk, F. M. Dobbs
78
NGS applications to assess vector mediated genotoxicity in genetic medicine
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A. M. Lynch
79
ecNGS analysis of induced mutagenesis; case studies with noteworthy nitrosamines
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Advances In Regulatory Genotoxicology

M. A. Beal
81
Modern in vitro screening tools to enhance quantitative chemical risk assessment
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A. Thienpont, E. Cho, A. Williams, M. J. Meier, C. L. Yauk, V. Rogiers, T. Vanhaecke, B. Mertens
82
The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRG™ cells
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A. K. Olsen, Y. Dirven, A. Sharma, X. Ma, C. Zheng, H. Dahl, K. Bjerve Gützkow, D. M. Eide
83
Assessing DNA damage in Testicular Germ Cells in the Comet Assay
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M. Davigo, K. Mengels, A. Opperhuizen, F. J. van Schooten, R. Talhout, A. H. Remels
84
Assessing the DNA damage potential of cigarette and iQOS emissions in human bronchial epithelial cells
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Human Biomonitoring

G. Jenkins, K. Munn, H. Naser, L. Williams, H. Haboubi, R. Lawrence, S. Doak
86
Understanding blood cell mutational biomarkers for biomonitoring and disease purposes
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L. Migliore
87
The importance of gene – environment interactions in Alzheimer disease and the emerging role of epigenetics
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V. Sousa, B. Rodrigues, J. Pires, F. Esteves, E. Neves, R. Santos, I. Gaivão, S. Costa, P. Jorge
88-89
Assessment of DNA damage in cumulus cells from infertile women using comet assay
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P. Hanak, K. Tomasova, N. Danesova, P. Vodicka, S. Vodenkova
90
Association of mitochondrial DNA copy number and telomere length with colorectal cancer patient outcomes
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M. Milić, I. Ožvald, K. Matković, H. Radašević, M. Nikolić, D. Božičević, L. Duh, M. Matovinović, M. Bituh
91
The use of combined different approaches in assessing the conditions and making prediction models in severely obese BMI ≥ 35 kg/m2 (FFQ, DII, anthropometric, biochemical and DNA damage parameters)
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Poster Presentations

M. G. Braz, D. B. Figueiredo, M. A. Silva, M. V. Destro, L. G. Braz
93
High exposure to anesthetic is associated with DNA damage and apoptosis in veterinarians
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D. Stefan, M. Mahier, E. Lequesne, F. Pouzoulet, L. De Marzi, F. Megnin-Chanet, J. L. Habrand, S. Gente, F. Sichel, C. Laurent
94
Oxidative and inflammatory effects in normal tissues of mice exposed whole body to combined treatments with conventional radiotherapy or protontherapy and a PARP inhibitor
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M. Gerić, M. Matković, G. Pehnec, A. Jurič, I. Brčić Karačonji, M. Milić, V. Kašuba, I. Jakovljević, S. Davila, J. Rinkovec, R. Godec, S. Žužul, I. Bešlić, A. M. Domijan, A. Cvitković, M. Sanković, A. Šumanovac, P. Wild, I. Guseva Canu, N. B. Hopf, G. Gajski
95
Evaluation of air pollution effects on human population: a Zagreb case
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C. Ladeira, R. Araújo, L. Ramalhete, H. Teixeira, C. R. C. Calado
96-97
Blood molecular profile to predict genotoxicity from exposure to antineoplastic drugs – a comparison with cytokinesis-block micronucleus assay results
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N. Kolar, E. E. Bankoglu, H. Stopper
98
Cellular effects of cannabinoids from Cannabis sativa in vitro
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N. S. A. Hadi, E. E. Bankoglu, H. Stopper
99
Metabolism and membrane transporters influence the genomic damage induced by pyrrolizidine alkaloids in a co-culture model system
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N. Fernández-Bertolez, A. Touzani, L. Martínez, J. Méndez, L. Ramos-Paz, A. T. Reis, S. Fraga, C. Costa, J. P. Teixeira, E. Pásaro, V. Valdiglesias, B. Laffon
100
Viability assay and DNA double strand break induction in nervous system cells exposed to cerium dioxide nanoparticles
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N. Fernández-Bertólez, M. Paz, A. Touzani, L. Ramos-Pan, S. Baúlde, J. Mosquera, A. Criado, E. Pásaro, B. Laffon, V. Valdiglesias
101
Analysis of cytotoxicity and genotoxicity of differently charged gold nanoparticles in human SH-SY5Y neuronal cells
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B Vuković-Gačić, M. Kračun-Kolarević, J. Jovanović Marić, J. Djordjević, Z. Gačić, R. Martinović, D. Joksimović, S. Kolarević
102
Assessment of sea pollution in the Boka Kotorska Bay, Montenegro with relocated gilthead sea bream (Sparus aurata) as an indicator of genotoxicity
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G. Parsadanyan, E. Aghajanova, G. Zalinyan, R. Markosyan, A. Sahakyan, A. Nersesyan
103
Buccal micronucleus cytome assay in Armenian diabetes patients
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T. Hashizume, S. Munakata, T. Takahashi, S. Kimuro, K. Ishimori, T. Watanabe
104
Development of a micronucleus test using the EpiAirway™ organotypic human airway model
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A. Rodríguez Pescador, L. Gutiérrez Romero, E. Blanco-González, M. Montes-Bayón, L. M. Sierra
105-106
Internalization, toxicity, and genotoxicity of ultra-small non-magnetic iron oxide (III) nanoparticles in cultured cell lines and Drosophila larvae in vivo
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L. Bálintová, A. Paolini, A. Masotti, M. Šramková
107
Genotoxicity of selected hydrogels loaded with iron oxide nanoparticles for potential application in regenerative medicine
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M. Blažíčková, K. Kozics
108
Determination of proliferation and genotoxic effect of thymol and acetyl thymol on in vitro intestinal model
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S. Rose, F. Ezan, T. Pecot, G. Baffet, S. Langouët
109
Development of automated image-based γH2AX and micronucleus assays for efficient genotoxicity and mutagenesis screening in the advanced 3D human hepatocytes Hepoid® model
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A. Masood, N. Ghaderi, S. Jaferinejad, D. Anderson, A. Wright, S. Kauser, M. Najafzadeh
110
The Role of UV exposure and novel compounds on the immunogenicity and genotoxicity of skin cancer
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K. Sugiyama, M. Kinoshita, P. Grúz, T. Kasamatsu, M. Honma
111
Epigenotoxic effects of Bisphenol-A mediated by its metabolite reducing DNA methylation
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M. Sima, Z. Simova, K. Vrbova, Z. Krejcik, J. Klema, D. Jandacka, R. J. Sram, J. Topinka, P. Rossner
112
Epigenetic changes in recreational runners from a clean and an air polluted locality
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A. Ambroz, P. Rossner Jr., A. Rossnerova, K. Honkova, A. Milcova, A. Pastorkova, J. Klema, J. Pulkrabova, J. Topinka, R. J. Sram
113-114
Impact of air pollution to oxidative stress markers in mothers and newborns (Summary of the long-term research in the Czechia)
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A. Testa, L. Kenzhina, C. Patrono, V. Palma, A. N. Mamyrbayeva, S. N. Lukashenko, Z. A. Baigazinov, D. B. Biyakhmetova, A. V. Panitskiy, E. Polivkina, F. F. Zhamaldinov
115
Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: a Human Biomonitoring Study
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J. Pavlikova, T. Cervena, A. Ambroz, P. Rossner, J. Topinka, R. J. Sram, T. Gramblicka, O. Parizek, D. Parizkova, J. Pulkrabova
116
Maternal diet quality and health status of newborns
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M. E. Hoogenboom-Geijer, T. Wilson, G. Papoutsoglou, A. Boswell, G. Hendriks
117
Extending ToxTracker with duplex sequencing to further understand the mode of action of genotoxic substances and their mutagenic potential
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A. Rodriguez-Garraus, G. Vales, M. Carlin, S. Suhonen, C. Passerino, J. Gómez, A. Tubaro, M. Pelin, J. Catalán
118
Effect of the oxidation status of reduced graphene oxide on the genotoxicity of human bronchial cells
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G. Hendriks, E. Adriaens, A. Allemang, J. van Benthem, J. Clements, G. Cole, M. Engel, A. Hamel, D. Kidd, S. Kellum, D. Kirkland, T. Kiyota, A. Myhre, V. Naëssens, S. Pfuhler, M. Roy, R. Settivari, M. Schuler, P. Vanparys, A. Zeller
119
An interlaboratory validation trial of the ToxTracker Assay for Genotoxic Mode of Action Assessment according to OECD guidelines
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Q. Vandoolaeghe, P. Evenden, M. Meryet-Figuiere, I. Vaudorne, P. Lebailly, V. Bouchart, R. Delépée
120
Evaluation of the impact of lifestyle parameters on global DNA methylation and hydroxymethylation in a French cohort
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M. Sramkova, E. Celkova, L. Balintova, M. Mesarosova
121
In vitro cell responses and cell-cell interactions upon xenobiotic exposure of renal and hepatic cells
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K. Kozics, M. Kapustova, D. Pangallo, A. Annusova, C. Geraci
122
Antimicrobial activities of biocompatible nanocapsules loaded with essential oils and their cyto/genotoxicity in human keratinocyte cell line
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E. Álvarez, R. Cué, L. Celada, M. D. Chiara, E. Blanco, L. M. Sierra
123
Role of oncometabolites succinate and fumarate in the response to induced DNA damage
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C. Boglári, C. Koelbert
124
Comparative analysis of miniaturized Ames assay variations for substances with ambiguous testing outcomes
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N. Vital, M. J. Silva, M. Kranendonk, H. Louro
125
In Vitro Cytotoxicity and Genotoxicity Assessment of Novel Cellulose Nanomaterials using intestinal cells
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C. Recoules, G. Mirey, M. Audebert
126
Effect of cell treatment procedure on in vitro genotoxicity assessment
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M. M. Nicolai, A. K. Weishaupt, M. Pirritano, A. Hartwig, M. Simon, T. Schwerdtle, A. Mangerich, J. Bornhorst
127
Utilizing the multicellular model organism C. elegans for investigations of genomic integrity
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H. Honkova, A. Rossnerova, J. Pavlikova, M. Sima, Z. Simova, P. Rossner, A. Ambroz, R. J. Sram, J. Topinka
128
New Findings from the Study "Healthy Ageing in an Industrial Environment"
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S. Das, S. Thakur, V. Cahais, C. Renard, C. Cuenin, L. Claeys, M. P. Cros, S. Keïta, A. Venuti, C. Sirand, F. Virard, Z. Herceg, M. Korenjak, J. Zavadil
129
Multi-omic and phenotypic reprogramming of oral cells following individual or combined exposures to arsenic and smokeless tobacco
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T. Morales-Ruiz, A. P. Rojas Moreno, L. G. Bermúdez Liscano, C. Bernal Forigua, D. Segorbe, M. I. Martínez-Macías, D. Córdoba-Cañero, B. Jurado Gámez, L. Caballero Ballesteros, M. D. S. Arenas de Larriva, R. R. Ariza, T. Roldán-Arjona
130
Identification of epigenetic biomarkers in COPD and lung cancer using minimally invasive samples
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S. Friese, T. Heinze, K. Lossow, A. P. Kipp, T. Schwerdtle
131
Variations of Dietary Trace Element Supply and its Consequences on Genomic Stability in the Murine Cerebellum
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C Patrono, V. Palma, A. Testa, M. Pierdomenico, M. Santoro, L. Bacchetta, A. Cemmi, I. Di Sarcina, J. Scifo, A. Verna, S. Rosciarelli, B. Benassi
132
Evaluation of Opuntia Ficus Indica (OFI) extract as a potential natural radioprotector
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B. Spremo-Potparevic, D. Topalović, L. Živković, M. Marković, A. Pirković
133
Prospective study of cytotoxic and genotoxic effects of Combretastatin A4
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I. Grávalos-Cano, A. Muñoz-Fernández, C. Ayala-Roldán, D. Segorbe, T. Morales-Ruiz, R. R. Ariza, T. Roldán-Arjona, M. I. Martínez-Macías
134
Sensitivity to temozolomide in glioblastoma: role of epigenetically regulated DNA repair genes
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Z. Salehi Moghaddam, S. Jafarinejad, C. Tait, R. Linforth, M. Isreb, D. Anderson, F. Sefat, M. Najafzadeh
135-136
Genotoxic effects of Taxifolin on lymphocytes and MDA-MB-231 breast cancer cell line
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Y. He, G. Nagel, T- Nikolova, M. C. Liebl, M. Christmann, P. O. Frappart, T. G. Hofmann
137
DNA replication stress and an ATR-HIPK2 signaling branch mediate genotoxicity of the mycotoxin Aflatoxin B1
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P. Braun, P. Fowler, G. Hendriks, G. Stoddart
138
A framework for interpreting in vitro genotoxicity data: Using mechanistic data to interpret positive results
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C. Plata-Calzado, L. Díez-Quijada, C. Medrano-Padial, A. I. Prieto, A. Jos, A. M. Cameán
139
Mutagenic and genotoxic potential produced by a mixture of the cyanotoxins Anatoxin-a and Cylindrospermopsin
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C. Plata-Calzado, L. Díez-Quijada, C. Medrano-Padial, A. I. Prieto, A. Jos, A. M. Cameán
140
Mutagenic and genotoxic assessment of pure anatoxin-a
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I. Barguilla, B. Guyot, V. Maguer-Satta
141
Stem cells as unique models to study long-term effects triggered by micro- and nanoplastic exposure: a focus on cell transformation and differentiation
PDF
K. Munn, H. Naser, L. Williams, H. Haboubi, R. Lawrence, S. Doak, G. Jenkins
142
Evaluating micronucleus frequency of circulating lymphocytes as a potential biomarker for oesophageal adenocarcinoma
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I. Barguilla, J. Domenech, S. Ballesteros, L. Rubio, R. Marcos, A. Hernández
143
Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
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M. Collía, E. Sáenz-Martínez, A. Vettorazzi, A. López de Cerain, A. Azqueta
144
In vivo standard and Fpg-modified comet assay: study of lysis conditions
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A. Mircheva, P. Vangrieken, S. Al-Nasiry, R. W. L. Godschalk, S. A. S. Langie
145
Investigation of base excision repair and oxidative stress in preeclampsia-complicated placentas – a pilot study
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F. Marcon, E. Siniscalchi, M. Salemi, C. D’Ippolito, F. Salani, G. Varalda, E. Medda, C. Fagnani
146
Heritability of baseline frequency of micronuclei in buccal cells: the SMP-twin study
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C. Álvarez-Herrera, S. Maisanaba, R. Rojas, M. Llana-Ruiz-Cabello, G. Repetto
147
Applying a test strategy to investigate toxic effects using Schyzosacchromyces pombe
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H. Naser, K. Munn, E. Grewal, H. Haboubi, L. Williams, R. Lawrence, S. Doak, G. Jenkins
148
Cytotoxic and Genotoxic Effects of Patient-derived Plasma on Healthy and Cancer-derived Cell Lines
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S. Jafarinejad, B. Abu Ras, M. Isreb, B. Jacob, A. Aziz, R. D. Bowen, R. Lagnado, W. H. C. Martin, M. Najafzadeh
149
A novel form of gallic acid to improve the compound bioavailability and cancer
PDF
M. Babonaite, M. Čepulis, J. Kazlauskaitė, J. R. Lazutka
150
Evaluation of Cytotoxicity and Genotoxicity of Nano-sized Plastic Particles
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Ó. Herrero, E. de la Peña
151
Activities of the Iberoamerican Network of Toxicology and Chemical Safety with the Hispanic Organization of Toxicologists
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E. Freire, G. Maia, C. Saraiva, A. Esteves, M. C. Fontes, L. Cardoso, I. Pires, I. Gaivão
152
Genomic instability in blood cells from bovine with spontaneous tumours: an OneHealth perspective
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T. Závodná, O. Pařízek, A. Milcová, Z. Krejčík, V. Jiřík, M. Stupák, J. Pulkrabová, J. Topinka
153
Analysis of Polycyclic Aromatic Hydrocarbons in Size Fractionized Atmospheric Aerosol Obtained by Personal Monitoring
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M. Morataya-Reyes, L. Vela, A. Villacorta, T. Venus, S. Pastor, i. Estrela-Lopis, R. Marcos, A. Hernández
154
Potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
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A. Villacorta, L. Rubio, M. Alaraby, M. Lopez-Mesas, V. Fuentes-Cebrian, O. H. Moriones, R. Marcos, A. Hernández
155
A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation
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B. Laffon, A. Hemadeh, T. Wences, N. Fernández-Bertólez, N. Cibeira, A. Maseda, J. L. Rodríguez-Villamil, J. C. Millán-Calenti, F. Valle-Inclán, J. Méndez, E. Pásaro, V. Valdiglesias, L. Lorenzo-López
156
Cognitive impairment due to biological ageing process related to DNA damage assessed by the comet assay
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A. Tavakolpournegari, B. Annangi, A. Villacorta, G. Banaei, J. Martin, S. Pastor, R. Marcos, A. Hernández
157
Hazard assessment of different-sized polystyrene nanoplastics in a human B-lymphoblastoid cell line
PDF
G. Banaei, A. Villacorta, A. Tavakolpournegari, A. Garcia-Rodriguez, J. Martin, R. Marcos, A. Hernández
158
Studying the effects of nanoplastics derived from teabags in an in vitro model of the intestinal epithelium
PDF
A. Hellmann, S. Weber, J. Lott
159
Establishment of an in vivo micronucleus assay using flow cytometry
PDF
J. Arribas Arranz, L. Cozzuto, J. Ponomarenko, R. Marcos, A. Hernández
160
Deciphering the effects induced by nanoplastics in peripheral blood immune cells
PDF
Y. Rivero, A. Curbelo, C. Rodiguez, N. Fernández
161
Mutagenic evaluation of a rodenticide in the in vivo micronucleus assay
PDF
R. Pribakovic, J. Bornhorst, E. E. Bankoglu, H. Stopper
162
Effect of pH and Duration of Electrophoresis on Comet Tail
PDF
T. A. Kurgina, N. A. Moor, M. M. Moor, K. N. Naumenko, A. A. Ukraintsev, O. I. Lavrik
163
HPF1 stimulates PARP1 and PARP2 to autoPARylation and histone modification
PDF
J. Gutiérrez, L. Rubio, B. Guyot, I. Barguilla, A. Villacorta, A. Bodelón, R. Marcos, A. Hernández
164
Long-term effects of PS and PET nanoplastics in lung cell lines
PDF
A. García-Rodríguez, J. Martín Pérez, A. Rocabert, L. Pareres, M. Alaraby, R. Marcos, A. Hernández
165
Drosophila melanogaster as bioindicator of microbiome dysfunction
PDF
J. Martín, G. Banaei, A. Tavakolpournegari, M. Morataya-Reyes, A. García-Rodriguez, R. Marcos, A. Hernández
166
Polystyrene nanoplastics: Surface- and size-dependent effects on human primary endothelial cells
PDF
A. L. Zolkiewski, B. C. Collins, C. K. Nolan, D. E. Bertrand, E. J. Haslam, F. J. Shaw, G. C. Stagg, H. L. Hinton, I. K. Philp, J. M. Tate
167
Proficiency Establishment of the OECD 488 Big Blue® Transgenic Rodent Somatic and Germ Cell Mutation Assay
PDF
A. Göpfert, N. Honarvar, L. Ma-Hock, V. Strauss, S. Treumann, W. Wohlleben, R. Landsiedel
168
Toxicological assessment of ZnO nanoforms to substantiate grouping
PDF
M. Usman, M. Woloshynowych, J. Carrilho Britto, I. Bilkevic, B. Glassar, S. Chapman, M. Ford-Adams, A. Desai, M. Bain, I. Tewfik, E. Volpi
169
Biomonitoring and predictive modelling of genomic instability in childhood obesity
PDF
S. Lacmanski, J. Graf, C. Nowak, H. Gehrke
170
Comet Assay validation of male germ cells isolated from seminiferous tubules
PDF
E. Demuynck, T. Vanhaecke, A. Thienpont, V. Rogiers, L. M. T. Winkelman, J. B. Beltman, A. Reus, F. Marcon, C. Bossa, A. Peijnenburg, K. Machera, D. Nikolopoulou, V. Hatzi, M. Paparella, Y. Kohl, S. Narui, S. Molerup, M. Dusinska, E. Runden-Pran, N. El Yamani, E. M. Longhin, C. Svendsen, A. Gutleb, J. Pennings, M. Luijten, C. Adam-Guillermin, O. Laurent, O. Armant, C. Pachoulide, H. Bouwmeester, G. Raitano, E. Benfenati, E. Wyrzykowska, M. Stepnik, T. Puzyn, M. Audebert, B. Mertens
171-172
Development of an AOP-based IATA for genotoxicity
PDF
L. Rubio, J. Gutiérrez, A. García-Rodríguez, R. Marcos, A. Hernández
173
Lung barrier establishment using Calu-3 cell line as an in vitro model to study the pulmonary effects of micro and nanoplastics
PDF
B. Stratenwerth, S. M. Geisen, L. Beltzig, S. J. Sturla, B. Kaina
174
Molecular dosimetry of alkylating agents: Quantification of O6-methylguanine and correlation with DNA double-strand breaks, apoptosis and senescence
PDF
A. M. Lynch, T. Harper, N. S. Holman, Y. Tessier, M. Guerard, P. Andersson, J. Elloway, J. Moggs, M. Crosby, L. Whiteley, C. den Besten, L. Jensen, K. Schaefer, W. Achanzar, C. Amuzie, E. Floettmann, J. D. Parry
175
Is the genetic toxicology assessment of oligonucleotide therapies warranted?
PDF
S. Mandriota, M. Tenan, A. P. Sappino
176
Carcinogenic traits of aluminium
PDF
H. Wu, Y. Y. Gong, J. Huntriss, M. N. Routledge
177
Transcriptome profiling of human hepatocyte cell line HHL-16 in response to aflatoxin B1
PDF
B. Annangi, A. Villacorta, M. López-Mesas, V. Fuentes-Cebrián, R. Marcos, A. Hernández
178
Hazard assessment of polystyrene nanoplastics in primary human nasal epithelial cells, focusing on the autophagic effects
PDF
Y. Lorenzo, B. O. Nicolaissen, G. Nguyen, K. Beraki, M. C. Moe, G. Petrovski, A. Noer, D. Krohn-Hansen, B. Nicolaissen
179
Effect of trypsin-EDTA on expression of DNA damage repair enzyme OGG1 in human limbal- and conjunctival- epithelial cells
PDF
K. Tomasova, S. Vodenkova, P. Vodicka, V. Claudino Bastos, L. Vodickova, R. Godschalk, S. A. S. Langie
180
A modified alkaline comet assay to measure base excision repair in mitochondria
PDF

HESI Workshop

P. A. White, S. Pfuhler
183
Quantitative Interpretation of In Vivo Mutagenicity Dose Response Data for Risk Assessment and Regulatory Decision-Making
PDF
M. A. Beal, G. Chen, K. L. Dearfield, M. Gi, B. Gollapudi, R. H. Heflich, K. Horibata, A. S. Long, D. Lovell, B. L. Parsons, S. Pfuhler, J. Wills, A. Zeller, G. Johnson, P. A. White
184
The interpretation of in vitro dose-response data for risk assessment and regulatory decision-making
PDF
G. Johnson
185
Nitrosamine impurity issues and potential resolutions
PDF
S. Zhang, J. P. Bercu, Z. Sobol, P. Escobar, P. Van, M. Schuler
186
In vivo genetic toxicity assessments for nitrosamines
PDF
A. M. Lynch
187
Defining a NOGEL for mutation induction in Muta™Mouse following exposure to N-Nitrosodimethylamine (NDMA)
PDF
R. Froetschl
188
Regulatory considerations related to mutagenic impurities in pharmaceuticals
PDF

HUMN Workshop

C. Bolognesi
191
The biology of buccal cells and the buccal micronucleus (MN) cytome assay
PDF
G. Wultsch, S. Knasmueller, M. Misik, M. Kundi, A. Nersesyan
192
Use of buccal cytome assays in the occupational exposure studies
PDF
S. Bonassi
193
Association of buccal MN cytome assay biomarkers with disease and their relevance for clinical studies
PDF
S. Knasmueller, M. Misik, M. Kundi, A. Nersesyan
194
Impact of nutrition and life style on formation of micronuclei
PDF
M. Fenech
195
Automation of the Buccal Micronucleus Cytome Assay
PDF
C. Schunck
196
Artificial Intelligence in Microscope-Based Imaging: Automation of the Buccal Micronucleus Cytome Assay?
PDF
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