Vol. 27 No. 1 (2023): 51st European Environmental Mutagenesis and Genomics Society (EEMGS) & 27th Spanish Environmental Mutagenesis and Genomics Society (SEMA) meeting | Spanish Journal of Environmental Mutagenesis and Genomics

M. Luijten, J. van Benthem, T. Morita, D. Kirkland, R. Corvi, P. Escobar, Y. Fujita, N. Koyama, F. Le Curieux, D. P. Lovell, A. Williams, S. D. Dertinger, S. Pfuhler, J. Pennings

Evaluation of the Standard Battery of In Vitro Genotoxicity Tests for Human Health Risk Assessment through Mathematical Modelling: A Report of the International Workshop on Genotoxicity Testing (IWGT)

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C. Beevers, Y. Uno, K. Meurer, S. Hamada, K. Hashimoto, L. Le Hegarat, D. Kirkland, M. J. LeBaron, F. Le Curieux, H. J. Martus, K. Masumura, W. Ohyama, D. J. Roberts, M. Vasquez, W. Whitwell, K. L. Witt

In Vivo Genotoxicity Testing Strategies: Report of the International Workshop on Genotoxicity Testing (IWGT)

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S. D. Dertinger, D. Li, C. Beevers, G. R. Douglas, R. H. Heflich, D. P. Lovell, D. J. Roberts, R. Smith, Y. Uno, A. Williams, K. L. Witt, A. Zeller, C. Zhou

31-32

Assessing the Quality and Making Appropriate Use of Historical Negative Control Data: A Report of the International Workshop on Genotoxicity Testing (IWGT)

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H. J. Martus, C. Beevers, S. Dertinger, R. Froetschl, R. Godschalk, B. Gollapudi, K. Hashimoto, D. Kirkland, S. Libertini, M. Luijten, T. McGovern, K. Sugiyama, P. White, A. Zeller

33-34

Summary of 8th IWGT in Ottawa, Canada

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New Approach Methodologies

F. Caloni

3Rs: from complexity to predictivity

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L. Le Hegarat

The human HepaRG cell line: a brief history of its use in genetic toxicology: advantages, limits and future directions

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J. Domenech, A. Villacorta, J. F. Ferrer, R. Llorens, R. Marcos, A. Hernández, J. Catalán

In vitro cell transforming capacity of different types of nano-plastics

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E. J. Burgers, C. J. S. Eugenio, M. M. Heldring, R. P. Sharma, L. S. Wijaya, B. van de Water, J. B. Beltman

In silico modelling of crosstalk between DNA damage and oxidative stress for prediction of cellular adversity

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L. Y. Hemeryck, M. De Graeve, T. Van Hecke, S. De Smet, L. Vanhaecke

Perspectives for DNA adductomics in large-scale exposomics: upscaling sample preparation and preprocessing data

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A. K. Olsen, S. Hartvelt, A. Jamalpoor, G. Hendriks, X. Ma, N. Duale

Oxidative Stress Disrupt Differentiation of Human Induced Pluripotent Stem Cells

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International Comet Assay Working Group

B. Žegura, T. Eleršek, M. Štampar

Advanced 3D cell models and zebrafish embryos: A bridge between in vitro and in vivo

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M. Manjanatha, J. Seo, N. Mei, X. Guo

Utility of 3D HepaRG spheroid model for testing genotoxicity using high-throughput CometChip platform

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M. Collía, A. Vettorazzi, A. López de Cerain, A. Azqueta

Use of the CometChip® for the in vitro, in vivo and Fpg-modifed assay

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L. Živković, S. Borozan, D. Topalović, V. Bajić, B. Spremo-Potparević

Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist

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M. L. Magenis, A. P. Damiani, I. O. Monteiro, L. S. Dagostin, R. Scussel, S. Nagashima, S. A. S. Langie, R. A. Pinho, V. M. Andrade

Maternal exercise during pregnancy modulates genetic and biochemical damage caused by high consumption of fructose in offspring

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Ecogenotoxicology

M. Farré, M. Llorca, E. Abad, K. Savvaa, A. Vega

The challenge of assessing contaminants of emerging concern and microplastics

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A. N. Jha

Assessing the Impact of Persistent and Emerging Contaminants on Aquatic Organisms

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F. Liu, K. S. Last, T. B. Henry, H. C. Reinardy

Hydrogen peroxide-induced oxidative damage in sea urchin (Paracentrotus lividus) DNA

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M. Hasanovic, T. Ćetković, B. Pourrut, L. Čaluk Klačar, M. Hadžić Omanović, A. Durmic-Pasic, S. Haverić, A. Haverić

Plant comet assay in biomonitoring of air pollution in Sarajevo, Bosnia and Herzegovina

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ECETOC

B. van Ravenzwaay

An Introduction to ECETOC’s workshops on Point of Departure and IVIVE modelling

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S. Schaller, R. Geci, S. Fragki, A. Paini

Physiologically Based Kinetic Modelling applications in Chemical Risk Assessment

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F. M. Zickgraf, V. Giri

Determination of point of departures based on high throughput in vitro metabolomics

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T. W. Gant

Summary of the ECETOC workshop from IVIVE to PODS – translating research methods to application

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R. A. Currie

Applying transcriptomic benchmark modelling for toxicological decision making

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DNA Repair, Chromatin Structure and Genome Stability

B. van de Kooij, A. Schreuder, R. S. Pavani, V. Garzero, A. van Hoeck, M. San Martin Alonso, D. Koerse, J. Boom, H. Mei, E. P. J. G. Cuppen, A. Nussenzweig, H. van Attikum, S. M. Noordermeer

Specific killing of BRCA1-deficient cancer cells by depletion of EXO1

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M. Jordano-Raya, R. R. Ariza, T. Roldán-Arjona, D. Córdoba-Cañero

Influence of orphan base and sequence context on the processing of AP sites by AP lyases in Arabidopsis thaliana

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E. E. Bankoglu, G. Kodandaraman, A. Geier, H. Stopper

Role of Phosphatase and Tensin homolog (Pten) in Insulin mediated DNA damage

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P. Weyerhäuser, G. Nagel, K. Raja, T. Nikolov, D. Pfeiffer, W. P. Roos, Y. He, P. O. Frappart, T. G. Hofmann

A direct role for HIPK2 in homology-directed DNA repair and the regulation of PARP inhibitor sensitivity

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A. R. Guedes, J. P. Soares, A. M. Silva , I. Gaivão

Could DNA damage be a useful biomarker of diagnosis and prognostic in human breast and colorectal cancer?

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B. Kaina

Senescence and cell death triggered by the DNA alkylation damage O6-methylguanine

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Machine Learning

S. Bryce, J. Bemis, S. Dertinger

Introduction to Machine Learning in Genetic Toxicology

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P. Rees, H. D. Summers, D. Harte, J. W. Wills, G. E. Johnson

Deep Neural Networks to Automate Scoring Of The Imaging Flow Cytometry In-Vitro Micronucleus Assay

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M. M. Heldring, L. S. Wijaya, M. Niemeijer, H. Yang, T. Lakhal, S. E. Le Dévédec, B. van de Water, J. B. Beltman

Towards a quantitative understanding of the DNA damage response through data-driven dynamical modeling

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New Challenges In Genotoxicity Assessment

A. Hernández

Understanding the health risks of exposure to micro- & nano-plastics

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M. Aloisi, P. Morciano, A. Tarola, D. Grifoni, A. M. G. Poma

Biological effects of chronic oral exposure to polystyrene nanoparticles in Drosophila melanogaster

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J. Kwasniewska

Recent achievements in micronuclei characterization

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M. Marin-Kuan, P. Rogeboz, Y. A. Hammel, H. Latado, C. Cottet-Fontannaz, B. Gentilli, P. Serrant, E. Omer, S. Koster, A. Patin

Novel methodology to assess genotoxicity in Food Contact Materials (FCM)

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error-corrected Next-Generation Sequencing

C. Valentine

Genomic Safety Assessment with ecNGS: The Next Generation

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J. Zavadil

NGS and toxicogenomic signatures of human carcinogens

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S. H. Reed, P. van Eijk, F. M. Dobbs

NGS applications to assess vector mediated genotoxicity in genetic medicine

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A. M. Lynch

ecNGS analysis of induced mutagenesis; case studies with noteworthy nitrosamines

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Advances In Regulatory Genotoxicology

M. A. Beal

Modern in vitro screening tools to enhance quantitative chemical risk assessment

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A. Thienpont, E. Cho, A. Williams, M. J. Meier, C. L. Yauk, V. Rogiers, T. Vanhaecke, B. Mertens

The GENOMARK transcriptomic biomarker demonstrates a high predictivity for genotoxic hazards and utility in potency ranking in human HepaRG™ cells

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A. K. Olsen, Y. Dirven, A. Sharma, X. Ma, C. Zheng, H. Dahl, K. Bjerve Gützkow, D. M. Eide

Assessing DNA damage in Testicular Germ Cells in the Comet Assay

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M. Davigo, K. Mengels, A. Opperhuizen, F. J. van Schooten, R. Talhout, A. H. Remels

Assessing the DNA damage potential of cigarette and iQOS emissions in human bronchial epithelial cells

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Human Biomonitoring

G. Jenkins, K. Munn, H. Naser, L. Williams, H. Haboubi, R. Lawrence, S. Doak

Understanding blood cell mutational biomarkers for biomonitoring and disease purposes

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L. Migliore

The importance of gene – environment interactions in Alzheimer disease and the emerging role of epigenetics

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V. Sousa, B. Rodrigues, J. Pires, F. Esteves, E. Neves, R. Santos, I. Gaivão, S. Costa, P. Jorge

88-89

Assessment of DNA damage in cumulus cells from infertile women using comet assay

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P. Hanak, K. Tomasova, N. Danesova, P. Vodicka, S. Vodenkova

Association of mitochondrial DNA copy number and telomere length with colorectal cancer patient outcomes

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M. Milić, I. Ožvald, K. Matković, H. Radašević, M. Nikolić, D. Božičević, L. Duh, M. Matovinović, M. Bituh

The use of combined different approaches in assessing the conditions and making prediction models in severely obese BMI ≥ 35 kg/m2 (FFQ, DII, anthropometric, biochemical and DNA damage parameters)

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Poster Presentations

M. G. Braz, D. B. Figueiredo, M. A. Silva, M. V. Destro, L. G. Braz

High exposure to anesthetic is associated with DNA damage and apoptosis in veterinarians

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D. Stefan, M. Mahier, E. Lequesne, F. Pouzoulet, L. De Marzi, F. Megnin-Chanet, J. L. Habrand, S. Gente, F. Sichel, C. Laurent

Oxidative and inflammatory effects in normal tissues of mice exposed whole body to combined treatments with conventional radiotherapy or protontherapy and a PARP inhibitor

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M. Gerić, M. Matković, G. Pehnec, A. Jurič, I. Brčić Karačonji, M. Milić, V. Kašuba, I. Jakovljević, S. Davila, J. Rinkovec, R. Godec, S. Žužul, I. Bešlić, A. M. Domijan, A. Cvitković, M. Sanković, A. Šumanovac, P. Wild, I. Guseva Canu, N. B. Hopf, G. Gajski

Evaluation of air pollution effects on human population: a Zagreb case

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C. Ladeira, R. Araújo, L. Ramalhete, H. Teixeira, C. R. C. Calado

96-97

Blood molecular profile to predict genotoxicity from exposure to antineoplastic drugs – a comparison with cytokinesis-block micronucleus assay results

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N. Kolar, E. E. Bankoglu, H. Stopper

Cellular effects of cannabinoids from Cannabis sativa in vitro

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N. S. A. Hadi, E. E. Bankoglu, H. Stopper

Metabolism and membrane transporters influence the genomic damage induced by pyrrolizidine alkaloids in a co-culture model system

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N. Fernández-Bertolez, A. Touzani, L. Martínez, J. Méndez, L. Ramos-Paz, A. T. Reis, S. Fraga, C. Costa, J. P. Teixeira, E. Pásaro, V. Valdiglesias, B. Laffon

100

Viability assay and DNA double strand break induction in nervous system cells exposed to cerium dioxide nanoparticles

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N. Fernández-Bertólez, M. Paz, A. Touzani, L. Ramos-Pan, S. Baúlde, J. Mosquera, A. Criado, E. Pásaro, B. Laffon, V. Valdiglesias

101

Analysis of cytotoxicity and genotoxicity of differently charged gold nanoparticles in human SH-SY5Y neuronal cells

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B Vuković-Gačić, M. Kračun-Kolarević, J. Jovanović Marić, J. Djordjević, Z. Gačić, R. Martinović, D. Joksimović, S. Kolarević

102

Assessment of sea pollution in the Boka Kotorska Bay, Montenegro with relocated gilthead sea bream (Sparus aurata) as an indicator of genotoxicity

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G. Parsadanyan, E. Aghajanova, G. Zalinyan, R. Markosyan, A. Sahakyan, A. Nersesyan

103

Buccal micronucleus cytome assay in Armenian diabetes patients

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T. Hashizume, S. Munakata, T. Takahashi, S. Kimuro, K. Ishimori, T. Watanabe

104

Development of a micronucleus test using the EpiAirway™ organotypic human airway model

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A. Rodríguez Pescador, L. Gutiérrez Romero, E. Blanco-González, M. Montes-Bayón, L. M. Sierra

105-106

Internalization, toxicity, and genotoxicity of ultra-small non-magnetic iron oxide (III) nanoparticles in cultured cell lines and Drosophila larvae in vivo

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L. Bálintová, A. Paolini, A. Masotti, M. Šramková

107

Genotoxicity of selected hydrogels loaded with iron oxide nanoparticles for potential application in regenerative medicine

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M. Blažíčková, K. Kozics

108

Determination of proliferation and genotoxic effect of thymol and acetyl thymol on in vitro intestinal model

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S. Rose, F. Ezan, T. Pecot, G. Baffet, S. Langouët

109

Development of automated image-based γH2AX and micronucleus assays for efficient genotoxicity and mutagenesis screening in the advanced 3D human hepatocytes Hepoid® model

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A. Masood, N. Ghaderi, S. Jaferinejad, D. Anderson, A. Wright, S. Kauser, M. Najafzadeh

110

The Role of UV exposure and novel compounds on the immunogenicity and genotoxicity of skin cancer

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K. Sugiyama, M. Kinoshita, P. Grúz, T. Kasamatsu, M. Honma

111

Epigenotoxic effects of Bisphenol-A mediated by its metabolite reducing DNA methylation

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M. Sima, Z. Simova, K. Vrbova, Z. Krejcik, J. Klema, D. Jandacka, R. J. Sram, J. Topinka, P. Rossner

112

Epigenetic changes in recreational runners from a clean and an air polluted locality

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A. Ambroz, P. Rossner Jr., A. Rossnerova, K. Honkova, A. Milcova, A. Pastorkova, J. Klema, J. Pulkrabova, J. Topinka, R. J. Sram

113-114

Impact of air pollution to oxidative stress markers in mothers and newborns (Summary of the long-term research in the Czechia)

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A. Testa, L. Kenzhina, C. Patrono, V. Palma, A. N. Mamyrbayeva, S. N. Lukashenko, Z. A. Baigazinov, D. B. Biyakhmetova, A. V. Panitskiy, E. Polivkina, F. F. Zhamaldinov

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Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: a Human Biomonitoring Study

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J. Pavlikova, T. Cervena, A. Ambroz, P. Rossner, J. Topinka, R. J. Sram, T. Gramblicka, O. Parizek, D. Parizkova, J. Pulkrabova

116

Maternal diet quality and health status of newborns

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M. E. Hoogenboom-Geijer, T. Wilson, G. Papoutsoglou, A. Boswell, G. Hendriks

117

Extending ToxTracker with duplex sequencing to further understand the mode of action of genotoxic substances and their mutagenic potential

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A. Rodriguez-Garraus, G. Vales, M. Carlin, S. Suhonen, C. Passerino, J. Gómez, A. Tubaro, M. Pelin, J. Catalán

118

Effect of the oxidation status of reduced graphene oxide on the genotoxicity of human bronchial cells

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G. Hendriks, E. Adriaens, A. Allemang, J. van Benthem, J. Clements, G. Cole, M. Engel, A. Hamel, D. Kidd, S. Kellum, D. Kirkland, T. Kiyota, A. Myhre, V. Naëssens, S. Pfuhler, M. Roy, R. Settivari, M. Schuler, P. Vanparys, A. Zeller

119

An interlaboratory validation trial of the ToxTracker Assay for Genotoxic Mode of Action Assessment according to OECD guidelines

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Q. Vandoolaeghe, P. Evenden, M. Meryet-Figuiere, I. Vaudorne, P. Lebailly, V. Bouchart, R. Delépée

120

Evaluation of the impact of lifestyle parameters on global DNA methylation and hydroxymethylation in a French cohort

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M. Sramkova, E. Celkova, L. Balintova, M. Mesarosova

121

In vitro cell responses and cell-cell interactions upon xenobiotic exposure of renal and hepatic cells

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K. Kozics, M. Kapustova, D. Pangallo, A. Annusova, C. Geraci

122

Antimicrobial activities of biocompatible nanocapsules loaded with essential oils and their cyto/genotoxicity in human keratinocyte cell line

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E. Álvarez, R. Cué, L. Celada, M. D. Chiara, E. Blanco, L. M. Sierra

123

Role of oncometabolites succinate and fumarate in the response to induced DNA damage

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C. Boglári, C. Koelbert

124

Comparative analysis of miniaturized Ames assay variations for substances with ambiguous testing outcomes

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N. Vital, M. J. Silva, M. Kranendonk, H. Louro

125

In Vitro Cytotoxicity and Genotoxicity Assessment of Novel Cellulose Nanomaterials using intestinal cells

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C. Recoules, G. Mirey, M. Audebert

126

Effect of cell treatment procedure on in vitro genotoxicity assessment

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M. M. Nicolai, A. K. Weishaupt, M. Pirritano, A. Hartwig, M. Simon, T. Schwerdtle, A. Mangerich, J. Bornhorst

127

Utilizing the multicellular model organism C. elegans for investigations of genomic integrity

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H. Honkova, A. Rossnerova, J. Pavlikova, M. Sima, Z. Simova, P. Rossner, A. Ambroz, R. J. Sram, J. Topinka

128

New Findings from the Study "Healthy Ageing in an Industrial Environment"

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S. Das, S. Thakur, V. Cahais, C. Renard, C. Cuenin, L. Claeys, M. P. Cros, S. Keïta, A. Venuti, C. Sirand, F. Virard, Z. Herceg, M. Korenjak, J. Zavadil

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Multi-omic and phenotypic reprogramming of oral cells following individual or combined exposures to arsenic and smokeless tobacco

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T. Morales-Ruiz, A. P. Rojas Moreno, L. G. Bermúdez Liscano, C. Bernal Forigua, D. Segorbe, M. I. Martínez-Macías, D. Córdoba-Cañero, B. Jurado Gámez, L. Caballero Ballesteros, M. D. S. Arenas de Larriva, R. R. Ariza, T. Roldán-Arjona

130

Identification of epigenetic biomarkers in COPD and lung cancer using minimally invasive samples

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S. Friese, T. Heinze, K. Lossow, A. P. Kipp, T. Schwerdtle

131

Variations of Dietary Trace Element Supply and its Consequences on Genomic Stability in the Murine Cerebellum

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C Patrono, V. Palma, A. Testa, M. Pierdomenico, M. Santoro, L. Bacchetta, A. Cemmi, I. Di Sarcina, J. Scifo, A. Verna, S. Rosciarelli, B. Benassi

132

Evaluation of Opuntia Ficus Indica (OFI) extract as a potential natural radioprotector

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B. Spremo-Potparevic, D. Topalović, L. Živković, M. Marković, A. Pirković

133

Prospective study of cytotoxic and genotoxic effects of Combretastatin A4

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I. Grávalos-Cano, A. Muñoz-Fernández, C. Ayala-Roldán, D. Segorbe, T. Morales-Ruiz, R. R. Ariza, T. Roldán-Arjona, M. I. Martínez-Macías

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Sensitivity to temozolomide in glioblastoma: role of epigenetically regulated DNA repair genes

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Z. Salehi Moghaddam, S. Jafarinejad, C. Tait, R. Linforth, M. Isreb, D. Anderson, F. Sefat, M. Najafzadeh

135-136

Genotoxic effects of Taxifolin on lymphocytes and MDA-MB-231 breast cancer cell line

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Y. He, G. Nagel, T- Nikolova, M. C. Liebl, M. Christmann, P. O. Frappart, T. G. Hofmann

137

DNA replication stress and an ATR-HIPK2 signaling branch mediate genotoxicity of the mycotoxin Aflatoxin B1

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P. Braun, P. Fowler, G. Hendriks, G. Stoddart

138

A framework for interpreting in vitro genotoxicity data: Using mechanistic data to interpret positive results

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C. Plata-Calzado, L. Díez-Quijada, C. Medrano-Padial, A. I. Prieto, A. Jos, A. M. Cameán

139

Mutagenic and genotoxic potential produced by a mixture of the cyanotoxins Anatoxin-a and Cylindrospermopsin

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C. Plata-Calzado, L. Díez-Quijada, C. Medrano-Padial, A. I. Prieto, A. Jos, A. M. Cameán

140

Mutagenic and genotoxic assessment of pure anatoxin-a

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I. Barguilla, B. Guyot, V. Maguer-Satta

141

Stem cells as unique models to study long-term effects triggered by micro- and nanoplastic exposure: a focus on cell transformation and differentiation

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K. Munn, H. Naser, L. Williams, H. Haboubi, R. Lawrence, S. Doak, G. Jenkins

142

Evaluating micronucleus frequency of circulating lymphocytes as a potential biomarker for oesophageal adenocarcinoma

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I. Barguilla, J. Domenech, S. Ballesteros, L. Rubio, R. Marcos, A. Hernández

143

Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process

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M. Collía, E. Sáenz-Martínez, A. Vettorazzi, A. López de Cerain, A. Azqueta

144

In vivo standard and Fpg-modified comet assay: study of lysis conditions

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A. Mircheva, P. Vangrieken, S. Al-Nasiry, R. W. L. Godschalk, S. A. S. Langie

145

Investigation of base excision repair and oxidative stress in preeclampsia-complicated placentas – a pilot study

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F. Marcon, E. Siniscalchi, M. Salemi, C. D’Ippolito, F. Salani, G. Varalda, E. Medda, C. Fagnani

146

Heritability of baseline frequency of micronuclei in buccal cells: the SMP-twin study

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C. Álvarez-Herrera, S. Maisanaba, R. Rojas, M. Llana-Ruiz-Cabello, G. Repetto

147

Applying a test strategy to investigate toxic effects using Schyzosacchromyces pombe

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H. Naser, K. Munn, E. Grewal, H. Haboubi, L. Williams, R. Lawrence, S. Doak, G. Jenkins

148

Cytotoxic and Genotoxic Effects of Patient-derived Plasma on Healthy and Cancer-derived Cell Lines

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S. Jafarinejad, B. Abu Ras, M. Isreb, B. Jacob, A. Aziz, R. D. Bowen, R. Lagnado, W. H. C. Martin, M. Najafzadeh

149

A novel form of gallic acid to improve the compound bioavailability and cancer

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M. Babonaite, M. Čepulis, J. Kazlauskaitė, J. R. Lazutka

150

Evaluation of Cytotoxicity and Genotoxicity of Nano-sized Plastic Particles

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Ó. Herrero, E. de la Peña

151

Activities of the Iberoamerican Network of Toxicology and Chemical Safety with the Hispanic Organization of Toxicologists

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E. Freire, G. Maia, C. Saraiva, A. Esteves, M. C. Fontes, L. Cardoso, I. Pires, I. Gaivão

152

Genomic instability in blood cells from bovine with spontaneous tumours: an OneHealth perspective

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T. Závodná, O. Pařízek, A. Milcová, Z. Krejčík, V. Jiřík, M. Stupák, J. Pulkrabová, J. Topinka

153

Analysis of Polycyclic Aromatic Hydrocarbons in Size Fractionized Atmospheric Aerosol Obtained by Personal Monitoring

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M. Morataya-Reyes, L. Vela, A. Villacorta, T. Venus, S. Pastor, i. Estrela-Lopis, R. Marcos, A. Hernández

154

Potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics

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A. Villacorta, L. Rubio, M. Alaraby, M. Lopez-Mesas, V. Fuentes-Cebrian, O. H. Moriones, R. Marcos, A. Hernández

155

A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation

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B. Laffon, A. Hemadeh, T. Wences, N. Fernández-Bertólez, N. Cibeira, A. Maseda, J. L. Rodríguez-Villamil, J. C. Millán-Calenti, F. Valle-Inclán, J. Méndez, E. Pásaro, V. Valdiglesias, L. Lorenzo-López

156

Cognitive impairment due to biological ageing process related to DNA damage assessed by the comet assay

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A. Tavakolpournegari, B. Annangi, A. Villacorta, G. Banaei, J. Martin, S. Pastor, R. Marcos, A. Hernández

157

Hazard assessment of different-sized polystyrene nanoplastics in a human B-lymphoblastoid cell line

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G. Banaei, A. Villacorta, A. Tavakolpournegari, A. Garcia-Rodriguez, J. Martin, R. Marcos, A. Hernández

158

Studying the effects of nanoplastics derived from teabags in an in vitro model of the intestinal epithelium

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A. Hellmann, S. Weber, J. Lott

159

Establishment of an in vivo micronucleus assay using flow cytometry

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J. Arribas Arranz, L. Cozzuto, J. Ponomarenko, R. Marcos, A. Hernández

160

Deciphering the effects induced by nanoplastics in peripheral blood immune cells

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Y. Rivero, A. Curbelo, C. Rodiguez, N. Fernández

161

Mutagenic evaluation of a rodenticide in the in vivo micronucleus assay

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R. Pribakovic, J. Bornhorst, E. E. Bankoglu, H. Stopper

162

Effect of pH and Duration of Electrophoresis on Comet Tail

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T. A. Kurgina, N. A. Moor, M. M. Moor, K. N. Naumenko, A. A. Ukraintsev, O. I. Lavrik

163

HPF1 stimulates PARP1 and PARP2 to autoPARylation and histone modification

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J. Gutiérrez, L. Rubio, B. Guyot, I. Barguilla, A. Villacorta, A. Bodelón, R. Marcos, A. Hernández

164

Long-term effects of PS and PET nanoplastics in lung cell lines

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A. García-Rodríguez, J. Martín Pérez, A. Rocabert, L. Pareres, M. Alaraby, R. Marcos, A. Hernández

165

Drosophila melanogaster as bioindicator of microbiome dysfunction

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J. Martín, G. Banaei, A. Tavakolpournegari, M. Morataya-Reyes, A. García-Rodriguez, R. Marcos, A. Hernández

166

Polystyrene nanoplastics: Surface- and size-dependent effects on human primary endothelial cells

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A. L. Zolkiewski, B. C. Collins, C. K. Nolan, D. E. Bertrand, E. J. Haslam, F. J. Shaw, G. C. Stagg, H. L. Hinton, I. K. Philp, J. M. Tate

167

Proficiency Establishment of the OECD 488 Big Blue® Transgenic Rodent Somatic and Germ Cell Mutation Assay

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A. Göpfert, N. Honarvar, L. Ma-Hock, V. Strauss, S. Treumann, W. Wohlleben, R. Landsiedel

168

Toxicological assessment of ZnO nanoforms to substantiate grouping

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M. Usman, M. Woloshynowych, J. Carrilho Britto, I. Bilkevic, B. Glassar, S. Chapman, M. Ford-Adams, A. Desai, M. Bain, I. Tewfik, E. Volpi

169

Biomonitoring and predictive modelling of genomic instability in childhood obesity

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S. Lacmanski, J. Graf, C. Nowak, H. Gehrke

170

Comet Assay validation of male germ cells isolated from seminiferous tubules

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E. Demuynck, T. Vanhaecke, A. Thienpont, V. Rogiers, L. M. T. Winkelman, J. B. Beltman, A. Reus, F. Marcon, C. Bossa, A. Peijnenburg, K. Machera, D. Nikolopoulou, V. Hatzi, M. Paparella, Y. Kohl, S. Narui, S. Molerup, M. Dusinska, E. Runden-Pran, N. El Yamani, E. M. Longhin, C. Svendsen, A. Gutleb, J. Pennings, M. Luijten, C. Adam-Guillermin, O. Laurent, O. Armant, C. Pachoulide, H. Bouwmeester, G. Raitano, E. Benfenati, E. Wyrzykowska, M. Stepnik, T. Puzyn, M. Audebert, B. Mertens

171-172

Development of an AOP-based IATA for genotoxicity

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L. Rubio, J. Gutiérrez, A. García-Rodríguez, R. Marcos, A. Hernández

173

Lung barrier establishment using Calu-3 cell line as an in vitro model to study the pulmonary effects of micro and nanoplastics

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B. Stratenwerth, S. M. Geisen, L. Beltzig, S. J. Sturla, B. Kaina

174

Molecular dosimetry of alkylating agents: Quantification of O6-methylguanine and correlation with DNA double-strand breaks, apoptosis and senescence

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A. M. Lynch, T. Harper, N. S. Holman, Y. Tessier, M. Guerard, P. Andersson, J. Elloway, J. Moggs, M. Crosby, L. Whiteley, C. den Besten, L. Jensen, K. Schaefer, W. Achanzar, C. Amuzie, E. Floettmann, J. D. Parry

175

Is the genetic toxicology assessment of oligonucleotide therapies warranted?

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S. Mandriota, M. Tenan, A. P. Sappino

176

Carcinogenic traits of aluminium

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H. Wu, Y. Y. Gong, J. Huntriss, M. N. Routledge

177

Transcriptome profiling of human hepatocyte cell line HHL-16 in response to aflatoxin B1

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B. Annangi, A. Villacorta, M. López-Mesas, V. Fuentes-Cebrián, R. Marcos, A. Hernández

178

Hazard assessment of polystyrene nanoplastics in primary human nasal epithelial cells, focusing on the autophagic effects

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Y. Lorenzo, B. O. Nicolaissen, G. Nguyen, K. Beraki, M. C. Moe, G. Petrovski, A. Noer, D. Krohn-Hansen, B. Nicolaissen

179

Effect of trypsin-EDTA on expression of DNA damage repair enzyme OGG1 in human limbal- and conjunctival- epithelial cells

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K. Tomasova, S. Vodenkova, P. Vodicka, V. Claudino Bastos, L. Vodickova, R. Godschalk, S. A. S. Langie

180

A modified alkaline comet assay to measure base excision repair in mitochondria

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HESI Workshop

P. A. White, S. Pfuhler

183

Quantitative Interpretation of In Vivo Mutagenicity Dose Response Data for Risk Assessment and Regulatory Decision-Making

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M. A. Beal, G. Chen, K. L. Dearfield, M. Gi, B. Gollapudi, R. H. Heflich, K. Horibata, A. S. Long, D. Lovell, B. L. Parsons, S. Pfuhler, J. Wills, A. Zeller, G. Johnson, P. A. White

184

The interpretation of in vitro dose-response data for risk assessment and regulatory decision-making

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G. Johnson

185

Nitrosamine impurity issues and potential resolutions

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S. Zhang, J. P. Bercu, Z. Sobol, P. Escobar, P. Van, M. Schuler

186

In vivo genetic toxicity assessments for nitrosamines

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A. M. Lynch